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Lead time is the length of time between the detection of a disease (usually based on new, experimental criteria) and its usual clinical presentation and diagnosis (based on traditional criteria). OR It is the time between early diagnosis with screening, and when diagnosis would have been made without screening. Lead time bias is that factor when comparing, in detection of disease, a traditional test with a new or experimental test but the outcome of the disease is unchanged; the new or experimental test merely identifies the disease earlier than the previous and thus gives the impression that survival is prolonged. It is an important factor when evaluating the effectiveness of a specific test.〔(Lead time bias - General Practice Notebook )〕 ==Relationship between screening and survival== (詳細はsymptoms appear. Early diagnosis through screening may not prolong the life of someone, just determine the propensity of the person to a disease or medical condition such as through DNA testing. No additional life span has been gained; the patient may be subject to added anxiety as the patient must live for longer with knowledge of the disease. For example, the genetic disorder Huntington's disease is diagnosed when symptoms appear around age 50, and the person dies around age 65. The typical patient therefore lives about 15 years after diagnosis. A genetic test at birth makes it possible to diagnose this disorder earlier. If this newborn baby dies around age 65, he or she will have "survived" 65 years after diagnosis, without having actually lived any longer than those diagnosed without DNA detection. Raw statistics can make screening appear to increase survival time (this gain is called lead time). If the person dies at a time in life that previously has been the usual course of the disease, than when detected by early screening, then the person's life has not been prolonged. Detection through advanced screening does not always mean prolong survival. Lead time bias can affect interpretation of the five-year survival rate. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「lead time bias」の詳細全文を読む スポンサード リンク
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